Pilot Feasibility Study of Combined Kidney and Hematopoietic Stem Cell Transplantation to Cure End-stage Renal Disease
Status: Recruiting
Location: See location...
Intervention Type: Biological, Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This pilot study of combined kidney and hematopoietic stem cell transplantation attempts to establish a protocol to induce immunological tolerance as a new strategy to prevent renal graft rejection. If successful, this strategy would restore renal function, while avoiding the risks associated with long-term standard anti-rejection therapy, and would represent the first option to cure end-stage renal disease.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: f
View:
• Patients, who are eligible for kidney transplantation
• Males or females 18 - 70 years of age.
• Subjects must have an HLA-matched sibling donor 25-70 years of age
• Men and women of reproductive potential must agree to use a reliable method of birth control
• Ability to understand and provide informed consent.
Locations
Other Locations
Switzerland
University Hospital Zurich
RECRUITING
Zurich
Contact Information
Primary
Thomas Fehr, MD
thomas.fehr@uzh.ch
Time Frame
Start Date: 2015-09
Estimated Completion Date: 2025-12
Participants
Target number of participants: 16
Treatments
Experimental: Tolerance
Combined kidney and hematopoietic stem cell transplantation from the same donor.
Related Therapeutic Areas
Sponsors
Leads: University of Zurich